Hiroki UEDA Associate Professor

Hiroki UEDA
Associate Professor

Researchmap

• Chiba University Institute for Advanced Academic Research / Health and Disease Omics Center

• Keywords

  RNA modification, Cancer Genomics, Nanopore Sequencing, Deep Learning, Epitranscriptomics, Single-cell Analysis, Spatial Omics

• Professional Memberships

  The Japanese Cancer Association, The RNA Society of Japan, The Molecular Biology Society of Japan

Research Theme

Elucidation of cancer progression mechanisms mediated by RNA modifications and development of analytical methodologies

Abstract

RNA modifications represent an evolutionarily ancient and highly conserved mechanism that governs a wide array of biological processes. Recent studies have revealed that dysregulation of these modifications induces aberrations in RNA splicing, degradation, and translation efficiency, significantly contributing to cancer progression and malignancy.
Despite their critical importance, robust methodologies for the comprehensive and high-precision detection of diverse RNA modifications remain in their infancy.
To address this gap, we are developing novel algorithms designed to analyze raw signal data from Nanopore sequencers using deep learning, enabling the identification of unknown RNA modifications at single-molecule resolution. Furthermore, we are advancing the construction of next-generation analytical platforms with a focus on applications in single-cell and spatial omics. By establishing these transcriptome-wide RNA modification analysis technologies, we aim to accelerate the elucidation of cancer pathogenesis.
Ultimately, this research seeks to foster the creation of more effective therapeutic strategies and the realization of personalized medicine based on clinical epitranscriptomics.