Eunyoung LEE Associate Professor

Eunyoung LEE
Associate Professor

Researchmap

• Chiba University Institute for Advanced Academic Research / Research Institute of Disaster Medicine

• Keywords

  Diabetes, Obesity, Lipid modification, Nutrients, Organ crosstalk, Incretin, Adipose tissue, NAFLD

• Professional Memberships

  The Japan Diabetes Society, European Association for the Study of Diabetes

Research Theme

Inter-Organ Network Analysis for Deciphering Metabolic Dysfunction Pathophysiology

Abstract

In modern society, the adoption of a Western-style diet, characterized by excessive intake of fat and sugar, combined with sedentary lifestyles, has led to energy imbalances and an increased prevalence of metabolic disorders such as obesity, diabetes, non-alcoholic fatty liver disease (NAFLD), and atherosclerosis.

My research focuses on the impact of imbalanced nutrient intake on various organs, and how it disrupts systemic glucose and energy metabolism through the organ network system. Through comprehensive analysis and molecular mechanism investigation, I aim to identify novel molecules and signaling pathways that can serve as biomarkers for the diagnosis and treatment of metabolic syndromes such as NAFLD and diabetes. So far, our research has revealed the importance of inter-organ crosstalk among adipose tissue, intestine, liver, and brain in the metabolic dysfunction induced by a high-fat diet.

Furthermore, in search of biomarkers for NAFLD and diabetes, we are conducting international collaborative studies with researchers at the University of Cambridge in the UK and Nanjing University in China.

Eunyoung LEE's Article / PressRelease