Naoko HASHIMOTO Assistant Professor

Naoko HASHIMOTO
Assistant Professor

Researchmap

• Chiba University Institute for Advanced Academic Research / Research Institute of Disaster Medicine

• Keywords

  Cellular senescence, lncRNA, ncRNA, Epigenome, Atherosclerosis, Transcription factor p53, Adipocyte, Age-related diseases, Vascular endothelium

• Professional Memberships

  The Japanese Society of Internal Medicine, The Japan Endocrine Society, The Japan Diabetes Society, Japan Thyroid Association, Japanese Cancer Association, The Molecular Biology Society of Japan, The Japan Society of Human Genetics

Research Theme

Roles of Aging-related Long Non-coding RNAs in Adipose Tissues and Blood Vessels

Abstract

With the increase in the incidence of age-related diseases such as diabetes and atherosclerosis, it has become clear that long non-coding RNAs (lncRNAs), which are not translated into proteins, play an essential role in the pathogenesis of various diseases.

Previous reports showed that tumor suppressor p53, also a regulator of aging, regulated some lncRNAs.

Elucidation of the mechanisms by which p53 acts on insulin target organs may lead to new therapeutic strategies for age-related diseases.

Therefore, to support longevity and good health, we are researching the mechanisms of aging-related p53-lncRNA complexes in adipose tissue and vascular endothelium.