Atsushi OKABE Associate Professor

Atsushi OKABE
Associate Professor

Researchmap

• Chiba University Institute for Advanced Academic Research / Graduate School of Medicine

• Keywords

  Chromatin structure, Epigenetics, Cancer, Next generation sequencer

• Professional Memberships

  Japanese Cancer Association, The Molecular Biology Society of Japan, The Japanese Society for Epigenetics

Research Theme

Analysis of chromatin structural aberrations in cancer

Abstract

DNA is stored in the nucleus by winding around histones and forming higher-order structures, allowing it to be controlled and accessed at the required times.
It is known that cell-type-specific regulation relies on epigenetic modifications and chromatin structures, and disruption of this structure leads to various diseases, including cancer.

I am conducting research primarily focused on gastric cancer using analysis techniques to identify chromatin structures, such as Hi-C and 4C-seq, aiming to elucidate structural abnormalities and their mechanisms that contribute to cancer initiation.